Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Nitromethane → 1-(3,5-Difluorophenyl)-2-nitroethanol
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Nitromethane | HCID 6375 | — |
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | 3,5-Difluorobenzaldehyde | HCID 588160 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | 1-(3,5-Difluorophenyl)-2-nitroethanol | HCID 68562553 | — |
반응 단계
Add nitromethane (200 mL) to a suspension of potassium carbonate (30 g) and 3,5-difluorobenzaldehyde (200 g) in tetrahydrofuran (600 mL) at room temperature. Stir at room temperature overnight, filter, wash with ethyl acetate and concentrate to give the desired compound as a crude oil (330 g) which is used in the next step without further purification.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07745438B2 |
| 출처 데이터셋 | uspto-grants-2010_06 |
| ORD ID | ord-2cf9865e0403426b8bcade080e174cea |
| 출처 메모 | uspto-grants-2010_06 |