Butyl bromide → 5-(R)-[2-(S)-Acetylamino-3-(3-butoxyphenyl)-1-(S)-hydroxypropyl]-2-(R)-(2,2-dimethylpropoxy)-3-(S)-methylmorpholine-4-carboxylic acid tert-butyl ester

반응식

Br[CH2:2][CH2:3][CH2:4][CH3:5].[C:6]([O:10][C:11]([N:13]1[CH:18]([C@@H:19]([OH:33])[C@@H:20]([NH:29][C:30](=[O:32])[CH3:31])[CH2:21][C:22]2[CH:27]=[CH:26][CH:25]=[C:24]([OH:28])[CH:23]=2)[CH2:17][O:16][C@@H:15]([O:34][CH2:35][C:36]([CH3:39])([CH3:38])[CH3:37])[C@@H:14]1[CH3:40])=[O:12])([CH3:9])([CH3:8])[CH3:7].C(=O)([O-])[O-].[Cs+].[Cs+]>CN(C)C=O.C(OCC)(=O)C>[C:6]([O:10][C:11]([N:13]1[C@@H:18]([C@@H:19]([OH:33])[C@@H:20]([NH:29][C:30](=[O:32])[CH3:31])[CH2:21][C:22]2[CH:27]=[CH:26][CH:25]=[C:24]([O:28][CH2:2][CH2:3][CH2:4][CH3:5])[CH:23]=2)[CH2:17][O:16][C@@H:15]([O:34][CH2:35][C:36]([CH3:39])([CH3:38])[CH3:37])[C@@H:14]1[CH3:40])=[O:12])([CH3:8])([CH3:9])[CH3:7]