6-[4-Methoxybenzyl-(6-morpholinopyridin-3-yl)amino]-4-[(trifluoroacetyl)amino]pyridine-3-carboxylic acid ethyl ester → HCID 67412646, 화합물

HRID 2035547노트

반응식

HRID 2035547 반응식
[CH2:1]([O:3][C:4]([C:6]1[CH:7]=[N:8][C:9]([N:19]([CH2:32][C:33]2[CH:38]=[CH:37][C:36]([O:39][CH3:40])=[CH:35][CH:34]=2)[C:20]2[CH:21]=[N:22][C:23]([N:26]3[CH2:31][CH2:30][O:29][CH2:28][CH2:27]3)=[CH:24][CH:25]=2)=[CH:10][C:11]=1[NH:12]C(=O)C(F)(F)F)=[O:5])[CH3:2]>CO.C(=O)([O-])[O-].[K+].[K+].O>[CH2:1]([O:3][C:4]([C:6]1[CH:7]=[N:8][C:9]([N:19]([CH2:32][C:33]2[CH:34]=[CH:35][C:36]([O:39][CH3:40])=[CH:37][CH:38]=2)[C:20]2[CH:21]=[N:22][C:23]([N:26]3[CH2:27][CH2:28][O:29][CH2:30][CH2:31]3)=[CH:24][CH:25]=2)=[CH:10][C:11]=1[NH2:12])=[O:5])[CH3:2]

참가 물질

5

반응물 1

HCID 866579436-[4-Methoxybenzyl-(6-morpholinopyridin-3-yl)amino]-4-[(trifluoroacetyl)amino]pyridine-3-carboxylic acid ethyl ester

생성물 1

HCID 67412646HCID 67412646, 화합물수율 100%

시약·촉매·용매 3

HCID 887Methanol용매HCID 962Water용매2회HCID 11430Potassium Carbonate용매

실험 절차

51 mg of 6-[4-methoxybenzyl-(6-morpholinopyridin-3-yl)amino]-4-[(trifluoroacetyl)amino]pyridine-3-carboxylic acid ethyl ester was dissolved in 5 mL of methanol, to which 3 mL of 2 mol/L potassium carbonate in water was added, and stirred at room temperature for 4 hours. To the reaction mixture water was added, extracted with ethyl acetate, the extract was washed with saturated saline, and dried on anhydrous sodium sulfate. The solvent was evaporated to obtain 42 mg (yield 100%) of the title compound as a light yellow solid.

후처리

  1. additionwas added
  2. extractionextracted with ethyl acetate
  3. washthe extract was washed with saturated saline
  4. dry with materialdried on anhydrous sodium sulfate
  5. customThe solvent was evaporated

출처 및 근거

ORD 기록
ord-9ee59c8823ed4d239c60dcbdef661608
출처 데이터셋
uspto-grants-2013_11
특허 번호
US08575153B2

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