2-Hydrazinyl-4-methylpyridine → N-[(E)-[8-[tert-butyl(dimethyl)silyl]oxyquinolin-2-yl]methylideneamino]-4-methylpyridin-2-amine

HRID 2035628노트

반응식

HRID 2035628 반응식
[NH:1]([C:3]1[CH:8]=[C:7]([CH3:9])[CH:6]=[CH:5][N:4]=1)[NH2:2].[Si:10]([O:17][C:18]1[CH:19]=[CH:20][CH:21]=[C:22]2[C:27]=1[N:26]=[C:25]([CH:28]=O)[CH:24]=[CH:23]2)([C:13]([CH3:16])([CH3:15])[CH3:14])([CH3:12])[CH3:11]>CCO>[Si:10]([O:17][C:18]1[CH:19]=[CH:20][CH:21]=[C:22]2[C:27]=1[N:26]=[C:25](/[CH:28]=[N:2]/[NH:1][C:3]1[CH:8]=[C:7]([CH3:9])[CH:6]=[CH:5][N:4]=1)[CH:24]=[CH:23]2)([C:13]([CH3:16])([CH3:15])[CH3:14])([CH3:11])[CH3:12]

참가 물질

4

반응물 2

HCID 122667392-Hydrazinyl-4-methylpyridineHCID 585670828-(Tert-butyldimethylsilyloxy)quinoline-2-carbaldehyde

생성물 1

HCID 67230767N-[(E)-[8-[tert-butyl(dimethyl)silyl]oxyquinolin-2-yl]methylideneamino]-4-methylpyridin-2-amine수율 81%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

2-Hydrazinyl-4-methylpyridine (0.280 g, 2.27 mmol) and 8-(tert-butyldimethylsilyloxy)quinoline-2-carbaldehyde (0.653 g, 2.27 mmol) were suspended in EtOH (6 mL) and stirred overnight at ambient temperature. The resulting suspension was filtered and the solid was washed with cold EtOH and dried in vacuo to provide the title compound (0.720 g; 81%).

후처리

  1. filtrationThe resulting suspension was filtered
  2. washthe solid was washed with cold EtOH
  3. customdried in vacuo

출처 및 근거

ORD 기록
ord-a644c984bf624698829627216e52a21a
출처 데이터셋
uspto-grants-2013_11
특허 번호
US08575145B2

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