참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Sodium Carbonate | HCID 10340 | — |
| 반응물 | 2-Amino-3-chloropyrazine | HCID 276224 | — |
| 반응물 | 4-Cyclohexyloxy-benzeneboronic acid | HCID 22289818 | — |
| 촉매 | HCID 178418397 | HCID 178418397 | — |
| 용매 | Water | HCID 962 | — |
| 용매 | 1,2-Dimethoxyethane | HCID 8071 | — |
| 생성물 | 3-[4-(Cyclohexyloxy)phenyl]pyrazin-2-amine | HCID 66748148 | 77.8% |
반응 단계
A mixture of sodium carbonate (491 mg), tetrakis(triphenylphosphine)palladium(0) (80 mg), 4-(cyclohexyloxy)phenylboronic acid (612 mg) and 3-chloropyrazin-2-amine (300 mg) in water (3 mL) and DME (15 mL) was stirred at 80° C. for 4 hr. Silica gel was added and the mixture was concentrated in vacuo. The residue was purified by column chromatography (silica gel, eluted with EtOAc in hexane) to give 3-[4-(cyclohexyloxy)phenyl]pyrazin-2-amine (485 mg) as a white solid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US08575154B2 |
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| 출처 데이터셋 | uspto-grants-2013_11 |
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| ORD ID | ord-ce29652cb9804afaa485558ed6eac362 |
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| 출처 메모 | uspto-grants-2013_11 |
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