Potassium Carbonate → 3-Methyl-8-[6-(3-methyl-1,2,4-thiadiazol-5-yl)pyridazin-3-yl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one

HRID 2036079노트

반응식

Cl[C:2]1[N:3]=[N:4][C:5]([C:8]2[S:12][N:11]=[C:10]([CH3:13])[N:9]=2)=[CH:6][CH:7]=1.Cl.Cl.[CH3:16][N:17]1[C:21](=[O:22])[C:20]2([CH2:27][CH2:26][NH:25][CH2:24][CH2:23]2)[N:19]([C:28]2[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=2)[CH2:18]1.C(=O)([O-])[O-].[K+].[K+]>>[CH3:16][N:17]1[C:21](=[O:22])[C:20]2([CH2:23][CH2:24][N:25]([C:2]3[N:3]=[N:4][C:5]([C:8]4[S:12][N:11]=[C:10]([CH3:13])[N:9]=4)=[CH:6][CH:7]=3)[CH2:26][CH2:27]2)[N:19]([C:28]2[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=2)[CH2:18]1

참가 물질

반응물 3

HCID 11430Potassium Carbonate

HCID 109218293-Chloro-6-(3-methyl-1,2,4-thiadiazol-5-yl)pyridazine

HCID 685583283-Methyl-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one dihydrochloride

생성물 1

HCID 685561523-Methyl-8-[6-(3-methyl-1,2,4-thiadiazol-5-yl)pyridazin-3-yl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one

실험 절차

The object product (85 mg, 33%) was obtained in the same manner as in Example 1 and using 3-chloro-6-(3-methyl-1,2,4-thiadiazol-5-yl)pyridazine (130 mg), 3-methyl-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one dihydrochloride (223 mg) and potassium carbonate (130 mg).

출처 및 근거

ORD 기록: ord-91bcad9257c74adea0a243b5aaf564bc
출처 데이터셋: uspto-grants-2013_11
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08575167B2

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