Potassium Carbonate → 1'-[6-(3-methyl-1,2,4-thiadiazol-5-yl)pyridazin-3-yl]-3H-spiro[2-benzofuran-1,3'-pyrrolidine]
반응식
Cl[C:2]1[N:3]=[N:4][C:5]([C:8]2[S:12][N:11]=[C:10]([CH3:13])[N:9]=2)=[CH:6][CH:7]=1.[NH:14]1[CH2:18][CH2:17][C:16]2([C:22]3[CH:23]=[CH:24][CH:25]=[CH:26][C:21]=3[CH2:20][O:19]2)[CH2:15]1.C(=O)([O-])[O-].[K+].[K+]>>[CH3:13][C:10]1[N:9]=[C:8]([C:5]2[N:4]=[N:3][C:2]([N:14]3[CH2:18][CH2:17][C:16]4([C:22]5[CH:23]=[CH:24][CH:25]=[CH:26][C:21]=5[CH2:20][O:19]4)[CH2:15]3)=[CH:7][CH:6]=2)[S:12][N:11]=1참가 물질
4
실험 절차
The object product (82 mg, 41%) was obtained in the same manner as in Example 1 and using 3-chloro-6-(3-methyl-1,2,4-thiadiazol-5-yl)pyridazine (120 mg), 3H-spiro[2-benzofuran-1,3′-pyrrolidine] (100 mg) and potassium carbonate (138 mg).