Spiro[chromene-2,3'-pyrrolidine] hydrochloride → 1047656-03-0
반응식
[ClH:1].[NH:2]1[CH2:6][CH2:5][C:4]2([CH:15]=[CH:14][C:13]3[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=3)[O:7]2)[CH2:3]1>CO.[C].[Pd]>[ClH:1].[NH:2]1[CH2:6][CH2:5][C:4]2([CH2:15][CH2:14][C:13]3[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=3)[O:7]2)[CH2:3]1참가 물질
4
실험 절차
Spiro[chromene-2,3′-pyrrolidine] hydrochloride (150 mg) synthesized in Example 33(1) and 5% palladium-carbon (30 mg) were suspended in methanol (10 mL), and the suspension was stirred overnight under a hydrogen atmosphere at room temperature. The catalyst was removed by filtration through celite, and the solvent was evaporated under reduced pressure to give the object product (130 mg, 86%).
후처리
- customThe catalyst was removed by filtration through celite
- customthe solvent was evaporated under reduced pressure
출처 및 근거
- ORD 기록
- ord-d62175440f334cfb87d01dd88cc4f2aa
- 출처 데이터셋
- uspto-grants-2013_11
- 특허 번호
- US08575167B2
반응 노트
불러오는 중…