Potassium Carbonate → 8-[6-(3-Methyl-1,2,4-oxadiazol-5-yl)pyridazin-3-yl]-2-phenyl-2,8-diazaspiro[4.5]decan-3-one
반응식
Cl[C:2]1[N:3]=[N:4][C:5]([C:8]2[O:12][N:11]=[C:10]([CH3:13])[N:9]=2)=[CH:6][CH:7]=1.Cl.[C:15]1([N:21]2[C:25](=[O:26])[CH2:24][C:23]3([CH2:31][CH2:30][NH:29][CH2:28][CH2:27]3)[CH2:22]2)[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1.C(=O)([O-])[O-].[K+].[K+]>>[CH3:13][C:10]1[N:9]=[C:8]([C:5]2[N:4]=[N:3][C:2]([N:29]3[CH2:28][CH2:27][C:23]4([CH2:22][N:21]([C:15]5[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=5)[C:25](=[O:26])[CH2:24]4)[CH2:31][CH2:30]3)=[CH:7][CH:6]=2)[O:12][N:11]=1참가 물질
4
실험 절차
The object product (142 mg, 64%) was obtained in the same manner as in Example 1 and using 3-chloro-6-(3-methyl-1,2,4-oxadiazol-5-yl)pyridazine (111 mg) obtained in Example 43(2), 2-phenyl-2,8-diazaspiro[4.5]decan-3-one hydrochloride (150 mg) and potassium carbonate (155 mg).
출처 및 근거
- ORD 기록
- ord-676db6d26da94427b333523f0d206813
- 출처 데이터셋
- uspto-grants-2013_11
- 특허 번호
- US08575167B2
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