Sodium Azide → (3-Azidopropyl)(triphenyl)phosphanium bromide

HRID 2036270노트

반응식

HRID 2036270 반응식
[Br-].[Br:2][CH2:3][CH2:4][CH2:5][P+:6]([C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1)([C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1.[N-:25]=[N+:26]=[N-:27].[Na+]>C(O)C.O>[Br-:2].[N:25]([CH2:3][CH2:4][CH2:5][P+:6]([C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1)([C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1)=[N+:26]=[N-:27]

참가 물질

4

반응물 2

HCID 33557Sodium AzideHCID 2723862(3-Bromopropyl)triphenylphosphonium bromide

생성물 1

HCID 53362697(3-Azidopropyl)(triphenyl)phosphanium bromide

시약·촉매·용매 1

HCID 19096565Water ethanol용매

실험 절차

(3-Bromo-propyl)-triphenyl-phosphonium bromide was dissolved in ethanol/water (1/1). To it sodium azide was added. The reaction mixture was heated up to reflux overnight. Solvents were removed by evaporation. The residue was extracted by dry ethanol. Filtered and evaporated to give crude (3-azido-propyl)-triphenyl-phosphonium bromide and was used directly for the next step reaction without further purification.

후처리

  1. temperatureThe reaction mixture was heated up
  2. temperatureto reflux overnight
  3. customSolvents were removed by evaporation
  4. extractionThe residue was extracted by dry ethanol
  5. filtrationFiltered
  6. customevaporated

출처 및 근거

ORD 기록
ord-ad8f3d5f84e949449b76dfa1c4991a85
출처 데이터셋
uspto-grants-2013_11
특허 번호
US08575176B2

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