2-(Butyloxy)-8-(methyloxy)-9-{3-[(2S)-tetrahydro-2-furanylamino]propyl}-9H-purin-6-amine → 2-(Butyloxy)-8-(methyloxy)-9-{3-[(tetrahydro-2H-pyran-2-ylmethyl)amino]propyl}-9H-purin-6-amine
반응식
[CH2:1]([O:5][C:6]1[N:14]=[C:13]2[C:9]([N:10]=[C:11]([O:24][CH3:25])[N:12]2[CH2:15][CH2:16][CH2:17][NH:18][C@@H:19]2[CH2:23][CH2:22][CH2:21]O2)=[C:8]([NH2:26])[N:7]=1)[CH2:2][CH2:3][CH3:4].F[C:28](F)(F)[C:29](O)=[O:30].C(OC1NC(N)=C2C(N=1)=NC(OC)=N2)CCC>>[CH2:1]([O:5][C:6]1[N:14]=[C:13]2[C:9]([N:10]=[C:11]([O:24][CH3:25])[N:12]2[CH2:15][CH2:16][CH2:17][NH:18][CH2:19][CH:23]2[CH2:22][CH2:21][CH2:28][CH2:29][O:30]2)=[C:8]([NH2:26])[N:7]=1)[CH2:2][CH2:3][CH3:4]참가 물질
3
실험 절차
Prepared similarly to Intermediate 14 from 2-(butyloxy)-8-(methyloxy)-1H-purin-6-amine trifluoroacetate and (tetrahydro-2H-pyran)-2-ylmethyl)amine hydrochloride.
출처 및 근거
- ORD 기록
- ord-2f51dc03989d4af794e66c8ce148257b
- 출처 데이터셋
- uspto-grants-2013_11
- 특허 번호
- US08575181B2
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