1,3-Dibromopropane → N2-Butyl-8-(methyloxy)-9-{3-[(tetrahydro-2H-pyran-4-ylmethyl)amino]propyl}-9H-purine-2,6-diamine
반응식
C(O[C:6]1[N:14]=[C:13]2[C:9]([N:10]=[C:11]([O:25][CH3:26])[N:12]2[CH2:15][CH2:16][CH2:17][NH:18][CH2:19][CH:20]2[CH2:24][CH2:23]CO2)=[C:8]([NH2:27])[N:7]=1)CCC.F[C:29](F)(F)[C:30]([OH:32])=O.[CH2:35]([NH:39]C1N=C2C(N=C(OC)N2)=C(N)N=1)[CH2:36][CH2:37][CH3:38].BrCCCBr.O1CCC(CN)CC1>>[CH2:35]([NH:39][C:6]1[N:14]=[C:13]2[C:9]([N:10]=[C:11]([O:25][CH3:26])[N:12]2[CH2:15][CH2:16][CH2:17][NH:18][CH2:19][CH:20]2[CH2:24][CH2:23][O:32][CH2:30][CH2:29]2)=[C:8]([NH2:27])[N:7]=1)[CH2:36][CH2:37][CH3:38]참가 물질
5
반응물 4
생성물 1
실험 절차
Prepared similarly to Intermediate 15 from N2-butyl-8-methoxy-9H-purine-2,6-diamine trifluoroacetic acid salt, 1,3-dibromopropane, and (tetrahydro-2H-pyran-4-ylmethyl)amine.
출처 및 근거
- ORD 기록
- ord-211a7e965724423da8ed2b4d3fe58796
- 출처 데이터셋
- uspto-grants-2013_11
- 특허 번호
- US08575181B2
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