(R)-3-Aminotetrahydrofuran → 2-{[(1S)-1-Methylbutyl]oxy}-8-(methyloxy)-9-{4-[(3R)-tetrahydro-3-furanylamino]butyl}-9H-purin-6-amine
반응식
[CH3:1][C@H:2]([O:6][C:7]1[N:15]=[C:14]2[C:10]([N:11]=[C:12]([O:27][CH3:28])[N:13]2[CH2:16][CH2:17][CH2:18][CH2:19][NH:20][CH:21]2[CH2:26]C[O:24][CH2:23][CH2:22]2)=[C:9]([NH2:29])[N:8]=1)[CH2:3][CH2:4][CH3:5].ClCCCCN1C(OC)=NC2C1=NC(O[C@@H](C)CCC)=NC=2N.O1CC[C@@H](N)C1>>[CH3:1][C@H:2]([O:6][C:7]1[N:15]=[C:14]2[C:10]([N:11]=[C:12]([O:27][CH3:28])[N:13]2[CH2:16][CH2:17][CH2:18][CH2:19][NH:20][C@@H:21]2[CH2:22][CH2:23][O:24][CH2:26]2)=[C:9]([NH2:29])[N:8]=1)[CH2:3][CH2:4][CH3:5]참가 물질
4
반응물 3
생성물 1
반응 조건
- 온도
- 70 °C
실험 절차
Prepared similarly to Intermediate 36 from 9-(4-chlorobutyl)-2-{[(1S)-1-methylbutyl]oxy}-8-(methyloxy)-9H-purin-6-amine and (3R)-tetrahydro-3-furanamine but with heating at 70° C. for an additional 20 hours.
출처 및 근거
- ORD 기록
- ord-a49b727e61cd492bb741f1d5910fdc77
- 출처 데이터셋
- uspto-grants-2013_11
- 특허 번호
- US08575181B2
반응 노트
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