Phthalimide → HCID 58459111, 화합물

HRID 2036561노트

반응식

HRID 2036561 반응식
[Br:1][C:2]1[N:6]2[CH:7]=[CH:8][CH:9]=[C:10]([Cl:11])[C:5]2=[N:4][C:3]=1[CH2:12]Cl.[C:14]1(=[O:24])[NH:18][C:17](=[O:19])[C:16]2=[CH:20][CH:21]=[CH:22][CH:23]=[C:15]12.C([O-])([O-])=O.[K+].[K+]>CN(C=O)C>[Br:1][C:2]1[N:6]2[CH:7]=[CH:8][CH:9]=[C:10]([Cl:11])[C:5]2=[N:4][C:3]=1[CH2:12][N:18]1[C:14](=[O:24])[C:15]2[C:16](=[CH:20][CH:21]=[CH:22][CH:23]=2)[C:17]1=[O:19]

참가 물질

5

반응물 3

HCID 6809PhthalimideHCID 11430Potassium CarbonateHCID 58459174HCID 58459174, 화합물

생성물 1

HCID 58459111HCID 58459111, 화합물

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

반응 조건

온도
80 °C

실험 절차

DMF (4.6 ml) was added to a mixture of 3-bromo-8-chloro-2-(chloromethyl)imidazo[1,2-a]pyridine (258 mg, 0.922 mmol), phthalimide (136 mg, 0.922 mmol) and K2CO3 (55.6 μL, 0.922 mmol). The reaction was heated at 80° C. After the reaction was complete, the mixture was initially partitioned between EtOAc and water, but the product did not dissolve readily. The product was collected by filteration of the mixture to give 2-((3-bromo-8-chloroimidazo[1,2-a]pyridin-2-yl)methyl)isoindoline-1,3-dione as a white solid.

후처리

  1. customthe mixture was initially partitioned between EtOAc and water
  2. dissolutionthe product did not dissolve readily
  3. customThe product was collected by filteration of the mixture

출처 및 근거

ORD 기록
ord-b6227c1a9e044234b09e621056089cf0
출처 데이터셋
uspto-grants-2013_11
특허 번호
US08575183B2

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