Dimethyl Sulfide → 1-(3-Pyridin-2-yl-imidazo[1,2-a]pyrimidin-2-yl)-ethylamine
반응식
C(OC(=O)[NH:10][CH:11]([C:13]1[N:14]=[C:15]2[N:20]=[CH:19][CH:18]=[CH:17][N:16]2[C:21]=1I)[CH3:12])C1C=CC=CC=1.CSC.[C:27](O)([C:29](F)(F)F)=O>>[N:10]1[CH:29]=[CH:27][CH:21]=[CH:13][C:11]=1[C:21]1[N:16]2[CH:17]=[CH:18][CH:19]=[N:20][C:15]2=[N:14][C:13]=1[CH:11]([NH2:10])[CH3:12]참가 물질
4
실험 절차
A mixture of [1-(3-iodo-imidazo[1,2-a]pyrimidin-2-yl)-ethyl]-carbamic acid benzyl ester (900 mg, 2.4 mmol) and dimethylsulfide (0.9 mL) in TFA (4.5 mL) was stirred at rt overnight. The mixture was concentrated in vacuo, dissolved in EtOAc washed with satd. sodium bicarbonate solution, dried over sodium sulfate, filtered and concentrated in vacuo to provide 1-(3-pyridin-2-yl-imidazo[1,2-a]pyrimidin-2-yl)-ethylamine: LC-MS (ESI) m/z 240.0 [M+H]+.