Topotecan → Camptothecin

HRID 2036761

반응식

HRID 2036761 반응식
[CH3:1][CH2:2][C@@:3]1([OH:31])[C:8](=[O:9])[O:7][CH2:6][C:5]2[C:10]([N:12]3[C:29](=[CH:30][C:4]1=2)[C:28]1[N:27]=[C:17]2[CH:18]=[CH:19][C:20](O)=[C:21](CN(C)C)[C:16]2=[CH:15][C:14]=1[CH2:13]3)=[O:11].CCC1C2CN3C(=O)C4COC([C@](O)(CC)C=4C=C3C=2N=C2C=1C=C(OC(N1CCC(N3CCCCC3)CC1)=O)C=C2)=O>>[CH3:1][CH2:2][C@@:3]1([OH:31])[C:8](=[O:9])[O:7][CH2:6][C:5]2[C:10]([N:12]3[C:29](=[CH:30][C:4]1=2)[C:28]1[N:27]=[C:17]2[C:16]([CH:21]=[CH:20][CH:19]=[CH:18]2)=[CH:15][C:14]=1[CH2:13]3)=[O:11]

참가 물질

3

반응물 2

HCID 60700TopotecanHCID 60838Irinotecan

생성물 1

HCID 24360Camptothecin

실험 절차

R1a=R1b=R2=H; Topotecan: R1a=—CH2NMe2, R1b=OH, and R2=H; Irinotecan: R1a=H, R1b=

출처 및 근거

ORD 기록
ord-d6bafcda32344ecbb5b39ac8b91b03b2
출처 데이터셋
uspto-grants-2013_11
특허 번호
US08575188B2

연결된 노트

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