참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Ammonia | HCID 222 | — |
| 반응물 | Anthranilic Acid | HCID 227 | — |
| 반응물 | Formamidine acetate | HCID 160693 | — |
| 용매 | 2-Methoxyethanol | HCID 8019 | — |
| 생성물 | 1,2-Dihydroquinazolin-2-one | HCID 344381 | — |
반응 단계
Anthranilic acid ED.5 (1.00 g, 4.27 mmol) is placed in 2-methoxyethanol (2.0 mL), combined with formamidine acetate (890 mg, 8.55 mmol) and heated to 125° C. for 20 h. The reaction mixture is added to aqueous NH3 (200 mL, 0.01 M), the precipitate is filtered off, dried and quinazolone Z.8 (817 mg, 79%) is obtained.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US08575203B2 |
|---|
| 출처 데이터셋 | uspto-grants-2013_11 |
|---|
| ORD ID | ord-5ab1d869f9fe4fdda7a60a86251bb9ec |
|---|
| 출처 메모 | uspto-grants-2013_11 |
|---|
