Water → 2-Hydroxy-4-phenylthiazole
반응식
[C:1]1([C:7](=O)[CH2:8][S:9][C:10]#[N:11])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[OH:13]S(O)(=O)=O.O>CC(O)=O>[C:1]1([C:7]2[NH:11][C:10](=[O:13])[S:9][CH:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1참가 물질
5
실험 절차
To a solution of 1-phenyl-2-thiocyanato-ethanone (20 g, 113 mmol) in HOAc (100 mL) was added 50% aqueous H2SO4 (20 mL). The mixture was refluxed for 10 min. The mixture was poured into water. The solid formed was collected by filtration to give crude 4-phenyl-3H-thiazol-2-one (20 g) which was used for the next step without further purification.
후처리
- temperatureThe mixture was refluxed for 10 min
- customThe solid formed
- filtrationwas collected by filtration
출처 및 근거
- ORD 기록
- ord-24148e6e66124618a3b0215e91a63f63
- 출처 데이터셋
- uspto-grants-2013_11
- 특허 번호
- US08575156B2
반응 노트
불러오는 중…