Triethylamine → 3-[(S)-1-(4-Chloro-phenyl)-ethylamino]-1-phenyl-propan-1-one

HRID 2037803노트

반응식

HRID 2037803 반응식
CCN(CC)CC.[Cl:8][C:9]1[CH:14]=[CH:13][C:12]([C@@H:15]([NH2:17])[CH3:16])=[CH:11][CH:10]=1.Cl[CH2:19][CH2:20][C:21]([C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1)=[O:22]>O1CCCC1>[Cl:8][C:9]1[CH:14]=[CH:13][C:12]([C@@H:15]([NH:17][CH2:19][CH2:20][C:21]([C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=2)=[O:22])[CH3:16])=[CH:11][CH:10]=1

참가 물질

5

반응물 3

HCID 8471TriethylamineHCID 702953-ChloropropiophenoneHCID 1550852(S)-(-)-1-(4-chlorophenyl)ethylamine

생성물 1

HCID 581093723-[(S)-1-(4-Chloro-phenyl)-ethylamino]-1-phenyl-propan-1-one

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

NEt3 (60 mL) followed by (S)-1-(4-chloro-phenyl)-ethylamine (20.5 g) was added to a solution of 3-chloro-1-phenyl-propan-1-one (23.2 g) in tetrahydrofuran (200 mL). The resulting mixture was stirred at room temperature overnight. Then, the solution was concentrated, water (100 mL) was added to the residue, and the resulting mixture was extracted with tert-butyl methyl ether. The combined organic extracts were washed with water and brine and dried (MgSO4). The title compound was obtained after removal of the solvent.

후처리

  1. concentrationThen, the solution was concentrated
  2. additionwater (100 mL) was added to the residue
  3. extractionthe resulting mixture was extracted with tert-butyl methyl ether
  4. washThe combined organic extracts were washed with water and brine
  5. dry with materialdried (MgSO4)

출처 및 근거

ORD 기록
ord-8efcffd0815042ea94ac45d8e6700528
출처 데이터셋
uspto-grants-2013_11
특허 번호
US08575156B2

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