Phenylmethyl 3-(4-hydroxybutyl)-1-piperidinecarboxylate → Phenylmethyl 3-(4-bromobutyl)-1-piperidinecarboxylate

반응식

[Br:1]CCCC1CCCCN1C(OCC1C=CC=CC=1)=O.O[CH2:22][CH2:23][CH2:24][CH2:25][CH:26]1[CH2:31][CH2:30][CH2:29][N:28]([C:32]([O:34][CH2:35][C:36]2[CH:41]=[CH:40][CH:39]=[CH:38][CH:37]=2)=[O:33])[CH2:27]1>>[Br:1][CH2:22][CH2:23][CH2:24][CH2:25][CH:26]1[CH2:31][CH2:30][CH2:29][N:28]([C:32]([O:34][CH2:35][C:36]2[CH:41]=[CH:40][CH:39]=[CH:38][CH:37]=2)=[O:33])[CH2:27]1

참가 물질

반응물 2

HCID 58306139Phenylmethyl 3-(4-hydroxybutyl)-1-piperidinecarboxylate2회

HCID 58306190Benzyl 2-(3-bromopropyl)piperidine-1-carboxylate

생성물 1

HCID 58306246Phenylmethyl 3-(4-bromobutyl)-1-piperidinecarboxylate

실험 절차

Prepared similarly to Intermediate 10 from phenylmethyl 3-(4-hydroxybutyl)-1-piperidinecarboxylate (for example, as prepared for Intermediate 23).

출처 및 근거

ORD 기록: ord-bb17b09370034ba3986c47d9233c0fe2
출처 데이터셋: uspto-grants-2013_11
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08575340B2

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