(1S,2R)-2-(2-((3-(1H-Benzo[d]imidazol-2-yl)propyl)(methyl)amino)ethyl)-4,4,6-trifluoro-1-isopropyl-1,2,3,4-tetrahydronaphthalen-2-ol → (1S,2R)-2-(2-((3-(1H-Benzo[d]imidazol-2-yl)propyl)(methyl)amino)ethyl)-4,4,6-trifluoro-1-isopropyl-1,2,3,4-tetrahydronaphthalen-2-yl cyclopropanecarboxylate

반응식

[NH:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[N:3]=[C:2]1[CH2:10][CH2:11][CH2:12][N:13]([CH3:33])[CH2:14][CH2:15][C@@:16]1([OH:32])[CH2:25][C:24]([F:27])([F:26])[C:23]2[C:18](=[CH:19][CH:20]=[C:21]([F:28])[CH:22]=2)[C@@H:17]1[CH:29]([CH3:31])[CH3:30].[CH:34]1([C:37](OC2C([2H])([2H])C([2H])([2H])C3C(=CC=C(F)C=3)C2(CCN(CCCC2NC3C=CC=CC=3N=2)C)C(C)C)=[O:38])[CH2:36][CH2:35]1>>[CH:34]1([C:37]([O:32][C@:16]2([CH2:15][CH2:14][N:13]([CH2:12][CH2:11][CH2:10][C:2]3[NH:3][C:4]4[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=4[N:1]=3)[CH3:33])[CH2:25][C:24]([F:27])([F:26])[C:23]3[C:18](=[CH:19][CH:20]=[C:21]([F:28])[CH:22]=3)[C@@H:17]2[CH:29]([CH3:31])[CH3:30])=[O:38])[CH2:36][CH2:35]1