2-Bromo-3'-chloroacetophenone → Ethyl 4-(3-chlorophenyl)-1,3-thiazole-2-carboxylate

HRID 2038361노트

반응식

HRID 2038361 반응식
[Cl:1][C:2]1[CH:3]=[C:4]([C:9]2[N:10]=[C:11]([C:14]([O:16][CH2:17][CH3:18])=[O:15])[S:12][CH:13]=2)[CH:5]=[CH:6][C:7]=1F.BrCC(C1C=CC=C(Cl)C=1)=O>>[Cl:1][C:2]1[CH:3]=[C:4]([C:9]2[N:10]=[C:11]([C:14]([O:16][CH2:17][CH3:18])=[O:15])[S:12][CH:13]=2)[CH:5]=[CH:6][CH:7]=1

참가 물질

3

반응물 2

HCID 387382-Bromo-3'-chloroacetophenoneHCID 61385370Ethyl 4-(3-chloro-4-fluorophenyl)-1,3-thiazole-2-carboxylate

생성물 1

HCID 10264991Ethyl 4-(3-chlorophenyl)-1,3-thiazole-2-carboxylate

실험 절차

The preparation of the title compound takes place in analogy to the synthesis of the compound from Example 2A starting with 2-bromo-1-(3-chlorophenyl)ethanone. 1.51 g (73% of theory) of the title compound are obtained.

출처 및 근거

ORD 기록
ord-ddb37b4bcaf54bbba78b2b58e6fe139a
출처 데이터셋
uspto-grants-2013_11
특허 번호
US08575357B2

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