Ethyl 4-(3-chlorophenyl)-1,3-thiazole-2-carboxylate → Ethyl 5-bromo-4-(3-chlorophenyl)-1,3-thiazole-2-carboxylate

HRID 2038363노트

반응식

HRID 2038363 반응식
[Br:1][C:2]1[S:6][C:5]([C:7]([O:9][CH2:10][CH3:11])=[O:8])=[N:4][C:3]=1[C:12]1[CH:17]=[CH:16][C:15](F)=[C:14]([Cl:19])[CH:13]=1.ClC1C=C(C2N=C(C(OCC)=O)SC=2)C=CC=1>>[Br:1][C:2]1[S:6][C:5]([C:7]([O:9][CH2:10][CH3:11])=[O:8])=[N:4][C:3]=1[C:12]1[CH:17]=[CH:16][CH:15]=[C:14]([Cl:19])[CH:13]=1

참가 물질

3

반응물 2

HCID 10264991Ethyl 4-(3-chlorophenyl)-1,3-thiazole-2-carboxylateHCID 70801639Ethyl 5-bromo-4-(3-chloro-4-fluorophenyl)-1,3-thiazole-2-carboxylate

생성물 1

HCID 70801641Ethyl 5-bromo-4-(3-chlorophenyl)-1,3-thiazole-2-carboxylate

실험 절차

The preparation of the title compound takes place in analogy to the synthesis of the compound from Example 4A starting with the compound of Example 3A. 1.95 g of the title compound having a purity of 65% (98% of theory) are obtained.

출처 및 근거

ORD 기록
ord-870d26214e084fd683defdd0971ace5a
출처 데이터셋
uspto-grants-2013_11
특허 번호
US08575357B2

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