Ethyl 5-bromo-4-(3-chlorophenyl)-1,3-thiazole-2-carboxylate → 4-(3-Chlorophenyl)-5-(3-cyanophenyl)-1,3-thiazole-2-carboxylic acid

HRID 2038370노트

반응식

HRID 2038370 반응식
[Cl:1][C:2]1[CH:3]=[C:4]([C:9]2[N:10]=[C:11]([C:22]([OH:24])=[O:23])[S:12][C:13]=2[C:14]2[CH:19]=[C:18](F)[CH:17]=[C:16](Cl)[CH:15]=2)[CH:5]=[CH:6][C:7]=1F.BrC1SC(C(OCC)=O)=[N:28][C:27]=1C1C=CC=C(Cl)C=1>>[Cl:1][C:2]1[CH:3]=[C:4]([C:9]2[N:10]=[C:11]([C:22]([OH:24])=[O:23])[S:12][C:13]=2[C:14]2[CH:19]=[CH:18][CH:17]=[C:16]([C:27]#[N:28])[CH:15]=2)[CH:5]=[CH:6][CH:7]=1

참가 물질

3

반응물 2

HCID 70801641Ethyl 5-bromo-4-(3-chlorophenyl)-1,3-thiazole-2-carboxylateHCID 708016444-(3-Chloro-4-fluorophenyl)-5-(3-chloro-5-fluorophenyl)-1,3-thiazole-2-carboxylic acid

생성물 1

HCID 703136774-(3-Chlorophenyl)-5-(3-cyanophenyl)-1,3-thiazole-2-carboxylic acid

실험 절차

The preparation of the title compound takes place in analogy to the synthesis of the compound from Example 8A starting with the compound from Example 5A. 556 mg of the title compound having a purity of 41% (46% of theory) are obtained.

출처 및 근거

ORD 기록
ord-c9b54eaf49634cc1835f3ad8ab805fdd
출처 데이터셋
uspto-grants-2013_11
특허 번호
US08575357B2

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