Sodium Bicarbonate → HCID 59557741, 화합물

HRID 2038478노트

반응식

HRID 2038478 반응식
[Br:1][C:2]1[CH:3]=[CH:4][C:5]([Cl:17])=[C:6]([CH:16]=1)[CH2:7][C:8]1[CH:15]=[CH:14][C:11]([CH:12]=O)=[CH:10][CH:9]=1.[C:18]([O-])(O)=O.[Na+]>C1(C)C=CC=CC=1>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([Cl:17])=[C:6]([CH2:7][C:8]2[CH:15]=[CH:14][C:11]([CH:12]=[CH2:18])=[CH:10][CH:9]=2)[CH:16]=1

참가 물질

4

반응물 2

HCID 516892Sodium BicarbonateHCID 59557754HCID 59557754, 화합물

생성물 1

HCID 59557741HCID 59557741, 화합물

시약·촉매·용매 1

HCID 1140Toluene용매2회

실험 절차

To a solution of Ph3PCH3I (0.97 g) in toluene (5 mL), KN(TMS)2 (0.5M in toluene, 4.8 mL) was added dropwise at room temperature. After 10 min, the solution of 4-(5-bromo-2-chlorobenzyl)benzaldehyde (intermediate AL) (0.62 g) in toluene (2 mL) was added dropwise. After 2 h, aqueous NaHCO3 was added to quench the reaction, and the resulting mixture was extracted with ethyl acetate. The organic layers were combined, washed with brine, and dried over Na2SO4. The solvent was evaporated under reduced pressure, and the product was purified by column chromatography to obtain pure intermediate AM (0.5 g).

후처리

  1. waitAfter 2 h
  2. customto quench
  3. customthe reaction
  4. extractionthe resulting mixture was extracted with ethyl acetate
  5. washwashed with brine
  6. dry with materialdried over Na2SO4
  7. customThe solvent was evaporated under reduced pressure
  8. customthe product was purified by column chromatography
  9. customto obtain pure intermediate

출처 및 근거

ORD 기록
ord-fc11bfeb9fac49d1812034dd9905e9f7
출처 데이터셋
uspto-grants-2013_11
특허 번호
US08575321B2

반응 노트

불러오는 중…