Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Methanol → (5S,8S)-3-(3-chlorophenyl)-7-((S)-2-(cyclopentyloxycarbonylamino)-3,3-dimethylbutanoyl)-2-oxo-1-oxa-3,7-diazaspiro[4.4]nonane-8-carboxylic acid
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Methanol | HCID 887 | — |
| 반응물 | Lithium Hydroxide | HCID 3939 | — |
| 반응물 | (5S,8S)-methyl-3-(3-chlorophenyl)-7-((S)-2-(cyclopentyloxycarbonylamino)-3,3-dimethylbutanoyl)-2-oxo-1-oxa-3,7-diazaspiro[4.4]nonane-8-carboxylate | HCID 59547346 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | (5S,8S)-3-(3-chlorophenyl)-7-((S)-2-(cyclopentyloxycarbonylamino)-3,3-dimethylbutanoyl)-2-oxo-1-oxa-3,7-diazaspiro[4.4]nonane-8-carboxylic acid | HCID 59547318 | 46.3% |
반응 단계
(5S,8S)-methyl-3-(3-chlorophenyl)-7-((S)-2-(cyclopentyloxycarbonylamino)-3,3-dimethylbutanoyl)-2-oxo-1-oxa-3,7-diazaspiro[4.4]nonane-8-carboxylate (C3) (22 mg, 41 μmol, 1 eq.) was diluted with dry THF (0.5 mL) then 1 M LiOH (82 μL, 82 μmol, 2 eq.) and MeOH (20 μL) was added. The reaction was stirred overnight at room temp. and concentrated to give 10 mg (19 μmol) of (5S,8S)-3-(3-chlorophenyl)-7-((S)-2-(cyclopentyloxycarbonylamino)-3,3-dimethylbutanoyl)-2-oxo-1-oxa-3,7-diazaspiro[4.4]nonane-8-carboxylic acid (D3). LC MS+: 522.35 at 3.14 min (10-90%, 3-5 min, Formic Acid).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08575208B2 |
| 출처 데이터셋 | uspto-grants-2013_11 |
| ORD ID | ord-59d921abbb714fa48c34ebcddc60dcf4 |
| 출처 메모 | uspto-grants-2013_11 |