Methanol → HCID 57869857, 화합물

HRID 2038617노트

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HRID 2038617 반응식
CO[C:3](=[O:13])[CH2:4][CH2:5][O:6][N:7]=[C:8]([O:10][CH2:11][CH3:12])[CH3:9].[CH3:14][NH2:15].[CH3:16]O>>[CH2:11]([O:10][C:8](=[N:7][O:6][CH2:5][CH2:4][C:3](=[O:13])[NH:15][CH2:14][CH3:16])[CH3:9])[CH3:12]

참가 물질

4

반응물 3

HCID 887MethanolHCID 6329MethylamineHCID 71331645Methyl 3-{[(1-ethoxyethylidene)amino]oxy}propanoate

생성물 1

HCID 57869857HCID 57869857, 화합물수율 57%

반응 조건

온도
60 °C

실험 절차

To a known compound, 3-(1-ethoxyethylideneaminooxy)-propanoic acid methyl ester (CAS No. 97164-30-2, 300 mg, 1.585 mmol) was added a 2 M solution of methylamine in methanol (7 ml), and the mixture was stirred at 60° C. for 13 hours. The reaction mixture was concentrated under reduced pressure, and the residue was purified by silica gel column chromatography to give N-(2-ethylcarbamoyl-ethoxy)-acetimidic acid ethyl ester (182 mg, 57% yield).

후처리

  1. concentrationThe reaction mixture was concentrated under reduced pressure
  2. customthe residue was purified by silica gel column chromatography

출처 및 근거

ORD 기록
ord-889bd530afc949de9b3e9d4632c9f1dc
출처 데이터셋
uspto-grants-2013_11
특허 번호
US08575391B2

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