Methylamine → 3-aminooxy-2,2,N-trimethyl-propionamide

HRID 2038638노트

반응식

HRID 2038638 반응식
C[O:2][C:3](=O)[C:4]([CH3:19])([CH3:18])[CH2:5][O:6][N:7]1C(=O)C2C(=CC=CC=2)C1=O.[CH3:21][NH2:22]>CO>[NH2:7][O:6][CH2:5][C:4]([CH3:19])([CH3:18])[C:3]([NH:22][CH3:21])=[O:2]

참가 물질

4

반응물 2

HCID 6329MethylamineHCID 593480263-(1,3-Dioxo-1,3-dihydro-isoindol-2-yloxy)-2,2-dimethyl-propionic acid methyl ester

생성물 1

HCID 553004123-aminooxy-2,2,N-trimethyl-propionamide

시약·촉매·용매 1

HCID 887Methanol용매

반응 조건

온도
60 °C

실험 절차

To 3-(1,3-dioxo-1,3-dihydro-isoindol-2-yloxy)-2,2-dimethyl-propionic acid methyl ester (800 mg) obtained in Step A was added a 40% solution of methylamine in methanol (6 ml), and the mixture was stirred at 60° C. for 13 hours. After the reaction mixture was concentrated under reduced pressure, dichloromethane was added to the residue, and insoluble matter was filtered. The filtrate was concentrated, and the residue was purified by silica gel column chromatography to give the title compound (202 mg).

후처리

  1. concentrationAfter the reaction mixture was concentrated under reduced pressure, dichloromethane
  2. additionwas added to the residue, and insoluble matter
  3. filtrationwas filtered
  4. concentrationThe filtrate was concentrated
  5. customthe residue was purified by silica gel column chromatography

출처 및 근거

ORD 기록
ord-5403a70ed98a4ec6966b2b917ec6d096
출처 데이터셋
uspto-grants-2013_11
특허 번호
US08575391B2

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