HCID 16214898, 화합물 → 4-{4-[3-(6-Trifluoromethyl-pyrimidin-4-yl)-ureido]-phenoxy}-pyridine-2-carboxylic acid methylamide

HRID 2039670노트

반응식

HRID 2039670 반응식
[CH3:1][NH:2][C:3]([C:5]1[CH:10]=[C:9]([O:11][C:12]2[CH:17]=[CH:16][C:15]([NH:18][C:19]([NH:21][C:22]3[CH:27]=[C:26]([C:28]([F:31])([F:30])[F:29])[N:25]=[CH:24][N:23]=3)=[O:20])=[C:14](F)[CH:13]=2)[CH:8]=[CH:7][N:6]=1)=[O:4].CNC(C1C=C(OC2C=CC(N)=CC=2)C=CN=1)=O>CCOC(C)=O>[CH3:1][NH:2][C:3]([C:5]1[CH:10]=[C:9]([O:11][C:12]2[CH:13]=[CH:14][C:15]([NH:18][C:19]([NH:21][C:22]3[CH:27]=[C:26]([C:28]([F:31])([F:29])[F:30])[N:25]=[CH:24][N:23]=3)=[O:20])=[CH:16][CH:17]=2)[CH:8]=[CH:7][N:6]=1)=[O:4]

참가 물질

4

반응물 2

HCID 16214898HCID 16214898, 화합물HCID 166551294-(4-Aminophenoxy)-N-methylpicolinamide

생성물 1

HCID 236342704-{4-[3-(6-Trifluoromethyl-pyrimidin-4-yl)-ureido]-phenoxy}-pyridine-2-carboxylic acid methylamide

시약·촉매·용매 1

HCID 8857Ethyl Acetate용매

실험 절차

The title compound was prepared in the same manner as 4-{3-fluoro-4-[3-(6-trifluoromethylpyrimidin-4-yl)ureido]phenoxy}pyridine-2-carboxylic-acid methylamide, replacing 4-(4-amino-3-fluoro-phenoxy)pyridine-2-carboxylic acid methylamide for 4-(4-aminophenoxy)pyridine-2-carboxylic acid methylamide. LC-MS m/z 433.1 [M+H]+; TLC Rf=0.8 (EtOAc).

출처 및 근거

ORD 기록
ord-c60f33495c5745acaed33212022146a8
출처 데이터셋
uspto-grants-2013_11
특허 번호
US08580798B2

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