HCID 16214898, 화합물 → 4-{4-[3-(6-Trifluoromethylpyrimidin-4-yl)ureido]phenoxy}-2-methylpyridine

HRID 2039671노트

반응식

HRID 2039671 반응식
CN[C:3]([C:5]1[CH:10]=[C:9]([O:11][C:12]2[CH:17]=[CH:16][C:15]([NH:18][C:19]([NH:21][C:22]3[CH:27]=[C:26]([C:28]([F:31])([F:30])[F:29])[N:25]=[CH:24][N:23]=3)=[O:20])=[C:14](F)[CH:13]=2)[CH:8]=[CH:7][N:6]=1)=O.CNC(C1C(OC2C=CC(N)=C(F)C=2)=CC=CN=1)=O.CC1C=C(OC2C=CC(N)=CC=2)C=CN=1>CCOC(C)=O>[F:31][C:28]([F:29])([F:30])[C:26]1[N:25]=[CH:24][N:23]=[C:22]([NH:21][C:19](=[O:20])[NH:18][C:15]2[CH:16]=[CH:17][C:12]([O:11][C:9]3[CH:8]=[CH:7][N:6]=[C:5]([CH3:3])[CH:10]=3)=[CH:13][CH:14]=2)[CH:27]=1

참가 물질

5

반응물 3

HCID 16214898HCID 16214898, 화합물HCID 230230754-(2-Methyl-4-pyridinyloxy)anilineHCID 86640576HCID 86640576, 화합물

생성물 1

HCID 236342714-{4-[3-(6-Trifluoromethylpyrimidin-4-yl)ureido]phenoxy}-2-methylpyridine

시약·촉매·용매 1

HCID 8857Ethyl Acetate용매

실험 절차

The title compound was prepared in the same manner as 4-{3-fluoro-4-[3-(6-trifluoromethyl-pyrimidin-4-yl)-ureido]-phenoxy}-pyridine-2-carboxylic-acid methyl-amide, replacing 4-(4-amino-3-fluorophenoxypyridine-2-carboxylic acid methylamide for 4-(2-methylpyridin-4-yloxy)phenylamine. LC-MS m/z 389.9 [M+H]+; TLC Rf=0.45 (EtOAc).

출처 및 근거

ORD 기록
ord-97a606810d5848c1b051513e0f590888
출처 데이터셋
uspto-grants-2013_11
특허 번호
US08580798B2

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