HCID 66922365, 화합물 → 1-Phenyl-1,3-dihydro-2H-pyrrolo[2,3-b]pyridin-2-one

HRID 2039831노트

반응식

HRID 2039831 반응식
Br[C:2]1(Br)[C:10]2[C:5](=[N:6][CH:7]=[CH:8][CH:9]=2)[N:4]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[C:3]1=[O:17]>C(O)C.[Pd]>[C:11]1([N:4]2[C:5]3=[N:6][CH:7]=[CH:8][CH:9]=[C:10]3[CH2:2][C:3]2=[O:17])[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=1

참가 물질

4

반응물 1

HCID 66922365HCID 66922365, 화합물

생성물 1

HCID 149872061-Phenyl-1,3-dihydro-2H-pyrrolo[2,3-b]pyridin-2-one수율 137.7%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 702Ethanol용매

실험 절차

The compound of step 2 (1.40 g, 3.80 mmol) was dissolved in ethanol (160 ml), and palladium on activated carbon (700 mg, 658 μmol, 10%) was added. The reaction mixture was hydrogenated (1 bar H2) at room temperature overnight. The mixture was filtered over celite, and the filtrate was evaporated under reduced pressure. Column chromatography of the residue on silica gel (EA (50%)/HEP) gave 1.10 g of the title compound.

후처리

  1. customat room temperature
  2. customovernight
  3. filtrationThe mixture was filtered over celite
  4. customthe filtrate was evaporated under reduced pressure

출처 및 근거

ORD 기록
ord-3d21900645694cf0bab83775b169a4c2
출처 데이터셋
uspto-grants-2013_11
특허 번호
US08580813B2

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