홈MCP워크벤치Skills
홈워크벤치알림마이페이지
llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
  1. 홈
  2. /반응

1,3-Oxazolidine → tert-Butyl (S)-6-tert-butoxycarbonylamino-2-[((9S,12R)-9-isopropyl-11-oxo-2,7-dioxa-10-azabicyclo[12.2.2]octadeca-1(17),14(18),15-trien-12-ylsulfamoyl)amino]hexanoate

HRID 2040022
노트
인쇄 미리보기

반응식

HRID 2040022 반응식
[C:1]([O:5][C:6]([NH:8][CH2:9][CH2:10][CH2:11][CH2:12][C@H:13]([NH:21][S:22](N1CCOC1=O)(=[O:24])=[O:23])[C:14]([O:16][C:17]([CH3:20])([CH3:19])[CH3:18])=[O:15])=[O:7])([CH3:4])([CH3:3])[CH3:2].[NH2:31][C@@H:32]1[CH2:47][C:46]2=[CH:48][CH:49]=[C:43]([CH:44]=[CH:45]2)[O:42][CH2:41][CH2:40][CH2:39][CH2:38][O:37][CH2:36][C@H:35]([CH:50]([CH3:52])[CH3:51])[NH:34][C:33]1=[O:53].O1CCNC1>C(#N)C>[C:1]([O:5][C:6]([NH:8][CH2:9][CH2:10][CH2:11][CH2:12][C@H:13]([NH:21][S:22](=[O:23])(=[O:24])[NH:31][C@@H:32]1[CH2:47][C:46]2=[CH:45][CH:44]=[C:43]([CH:49]=[CH:48]2)[O:42][CH2:41][CH2:40][CH2:39][CH2:38][O:37][CH2:36][C@H:35]([CH:50]([CH3:51])[CH3:52])[NH:34][C:33]1=[O:53])[C:14]([O:16][C:17]([CH3:18])([CH3:19])[CH3:20])=[O:15])=[O:7])([CH3:3])([CH3:2])[CH3:4]
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

5

반응물 3

HCID 5366831,3-OxazolidineHCID 58360483(9S,12R)-12-Amino-9-isopropyl-2,7-dioxa-10-azabicyclo[12.2.2]octadeca-1(17),14(18),15-trien-11-one2회HCID 67028806tert-butyl(S)-6-tert-butoxycarbonylamino-2-(2-oxooxazolidine-3-sulfonylamino)hexanoate

생성물 1

HCID 67320439tert-Butyl (S)-6-tert-butoxycarbonylamino-2-[((9S,12R)-9-isopropyl-11-oxo-2,7-dioxa-10-azabicyclo[12.2.2]octadeca-1(17),14(18),15-trien-12-ylsulfamoyl)amino]hexanoate
수율 14.6%

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

A solution of 387 mg (0.858 mmol) of tert-butyl (S)-6-tert-butoxycarbonylamino-2-(2-oxooxazolidine-3-sulfonylamino)hexanoate and 250 mg (0.780 mmol) of (9S,12R)-12-amino-9-isopropyl-2,7-dioxa-10-azabicyclo[12.2.2]octadeca-1(17),14(18),15-trien-11-one (compound 1-1E) in 15 ml of acetonitrile was stirred at 80° C. After 1 day (d), the same amount of the oxazolidine was again added, and the mixture was stirred for 1 d. The reaction mixture was then concentrated and the residue was purified by prep. HPLC. Product-containing fractions were combined, the acetonitrile was evaporated off, made slightly alkaline with sat. NaHCO3 solution and extracted several times with ethyl acetate. The combined organic phases were dried over Na2SO4, filtered and concentrated. 78 mg of the title compound were obtained.

후처리

  1. concentrationThe reaction mixture was then concentrated
  2. customthe residue was purified by prep
  3. customthe acetonitrile was evaporated off
  4. extractionextracted several times with ethyl acetate
  5. dry with materialThe combined organic phases were dried over Na2SO4
  6. filtrationfiltered
  7. concentrationconcentrated

출처 및 근거

ORD 기록
ord-cf978afc64a640ab96697133bd334a61
출처 데이터셋
uspto-grants-2013_11
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08580777B2

반응 노트

불러오는 중…

이 페이지에서참가 물질실험 절차후처리출처 및 근거반응 노트