3-Fluoro-4-hydroxybenzaldehyde → 4-(2-Fluoro-4-formyl-phenoxy)-naphthalene-1-carbonitrile

반응식

[F:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][C:9]=1[OH:10])[CH:5]=[O:6].F[C:12]1[C:21]2[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=2)[C:15]([C:22]#[N:23])=[CH:14][CH:13]=1>>[F:1][C:2]1[CH:3]=[C:4]([CH:5]=[O:6])[CH:7]=[CH:8][C:9]=1[O:10][C:12]1[C:21]2[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=2)[C:15]([C:22]#[N:23])=[CH:14][CH:13]=1

참가 물질

반응물 2

HCID 5872503-Fluoro-4-hydroxybenzaldehyde

HCID 27367341-Cyano-4-fluoronaphthalene

생성물 1

HCID 866231414-(2-Fluoro-4-formyl-phenoxy)-naphthalene-1-carbonitrile

실험 절차

4-(2-Fluoro-4-formyl-phenoxy)-naphthalene-1-carbonitrile was prepared from 3-Fluoro-4-hydroxybenzaldehyde and 4-Fluoro-naphthalene-1-carbonitrile following General Procedure A. 1H NMR (400 MHz, CDCl3) δ 9.99 (d, J=1.95 Hz, 1H), 8.38 (d, J=8.6 Hz, 1H), 8.27 (d, J=8.6 Hz, 1H), 7.77-7.84 (3H), 7.69-7.74 (2H), 7.29 (d, J=7.43 Hz, 1H), 6.83 (d, J=7.83 Hz, 1H).

출처 및 근거

ORD 기록: ord-97469de574ac418f9c2a6b6f66063008
출처 데이터셋: uspto-grants-2013_11
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08580832B2

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