Oxalyl chloride → 3-Cyano-5-(trifluoromethoxy)benzoyl chloride

HRID 2040514노트

반응식

HRID 2040514 반응식
[C:1](Cl)(=O)[C:2]([Cl:4])=[O:3].[C:7]([C:9]1[CH:10]=C([CH:15]=[C:16]([O:18][C:19]([F:22])([F:21])[F:20])[CH:17]=1)C(O)=O)#[N:8]>CN(C=O)C>[C:7]([C:9]1[CH:10]=[C:1]([CH:15]=[C:16]([O:18][C:19]([F:20])([F:22])[F:21])[CH:17]=1)[C:2]([Cl:4])=[O:3])#[N:8]

참가 물질

4

반응물 2

HCID 65578Oxalyl chlorideHCID 219425323-Cyano-5-(trifluoromethoxy)benzoic acid

생성물 1

HCID 866469923-Cyano-5-(trifluoromethoxy)benzoyl chloride

시약·촉매·용매 1

HCID 6228Dimethylformamide촉매

실험 절차

Oxalyl chloride (2.0 M in DCM, 0.636 mL, 1.272 mmol) was added to neat 3-cyano-5-(trifluoromethoxy)benzoic acid (98 mg, 0.424 mmol) and one drop of DMF was added. The reaction mixture was stirred at room temperature for 30 min and then concentrated under reduced pressure.

후처리

  1. additionwas added
  2. concentrationconcentrated under reduced pressure

출처 및 근거

ORD 기록
ord-3aedfb3f6d974af794f663fc056441b3
출처 데이터셋
uspto-grants-2013_11
특허 번호
US08580841B2

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