Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HCID 68562982, 화합물 → (2R,5S)-2-(2,2-dimethylpropoxy)-5-hydroxymethylmorpholine-4-carboxylic acid tert-butyl ester
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | HCID 68562982 | HCID 68562982 | — |
| 반응물 | HCID 178418361 | HCID 178418361 | — |
| 촉매 | Palladium hydroxide | HCID 9942167 | — |
| 용매 | Methanol | HCID 887 | — |
| 생성물 | (2R,5S)-2-(2,2-dimethylpropoxy)-5-hydroxymethylmorpholine-4-carboxylic acid tert-butyl ester | HCID 68564170 | — |
반응 단계
Stir (2R,5S)-5-benzyloxymethyl-2-(2,2-dimethylpropoxy)-morpholine-4-carboxylic acid tert-butyl ester (7.05 g, 17.92 mmol) and 20% palladium hydroxide on carbon in methanol (150 mL) under 1 atmosphere of hydrogen gas at room temperature for 12 hours. Filter and concentrate to give the desired compound as a thick oil which is used directly in the next step without further purification (5.10 g).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07745438B2 |
| 출처 데이터셋 | uspto-grants-2010_06 |
| ORD ID | ord-b4a8cf8faafe4769ad32a73e4db765cb |
| 출처 메모 | uspto-grants-2010_06 |