9-((3aR,4R,6R,6aR)-6-(((3-(azidomethyl)cyclobutyl)(methyl)amino)methyl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)-9H-purin-6-amine → 9-((3aR,4R,6R,6aR)-6-(((3-(aminomethyl)cyclobutyl)(methyl)amino)methyl)-2,2-dimethyltetrahydro furo[3,4-d][1,3]dioxol-4-yl)-9H-purin-6-amine

HRID 2040625노트

반응식

HRID 2040625 반응식
[N:1]([CH2:4][CH:5]1[CH2:8][CH:7]([N:9]([CH2:11][C@@H:12]2[C@H:16]3[O:17][C:18]([CH3:21])([CH3:20])[O:19][C@H:15]3[C@H:14]([N:22]3[CH:30]=[N:29][C:28]4[C:23]3=[N:24][CH:25]=[N:26][C:27]=4[NH2:31])[O:13]2)[CH3:10])[CH2:6]1)=[N+]=[N-]>CO.[Pd]>[NH2:1][CH2:4][CH:5]1[CH2:6][CH:7]([N:9]([CH2:11][C@@H:12]2[C@H:16]3[O:17][C:18]([CH3:21])([CH3:20])[O:19][C@H:15]3[C@H:14]([N:22]3[CH:30]=[N:29][C:28]4[C:23]3=[N:24][CH:25]=[N:26][C:27]=4[NH2:31])[O:13]2)[CH3:10])[CH2:8]1

참가 물질

4

반응물 1

HCID 866661089-((3aR,4R,6R,6aR)-6-(((3-(azidomethyl)cyclobutyl)(methyl)amino)methyl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)-9H-purin-6-amine

생성물 1

HCID 677761929-((3aR,4R,6R,6aR)-6-(((3-(aminomethyl)cyclobutyl)(methyl)amino)methyl)-2,2-dimethyltetrahydro furo[3,4-d][1,3]dioxol-4-yl)-9H-purin-6-amine

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

Pd/C (10 mg) was added to a solution of 9-((3aR,4R,6R,6aR)-6-(((3-(azidomethyl)cyclobutyl)(methyl)amino)methyl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)-9H-purin-6-amine (90 mg, 0.21 mmol) in MeOH (6 ml). The mixture was stirred at RT overnight under an atmosphere of H2. The mixture was filtered and the filtrate was concentrated to obtain the title compound which was used directly in the next step.

후처리

  1. filtrationThe mixture was filtered
  2. concentrationthe filtrate was concentrated

출처 및 근거

ORD 기록
ord-22e6a54b08e64acd94520e74991a20f3
출처 데이터셋
uspto-grants-2013_11
특허 번호
US08580762B2

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