[CH2:1]=[C:2]1[CH2:7][CH2:6]N(C2C([N+]([O-])=O)=CC=CN=2)[CH2:4][CH2:3]1.[Li].C[Si]([N-][Si](C)(C)C)(C)C.[Li].[O:28]1[C:32]2(CCC(=O)CC2)[O:31][CH2:30][CH2:29]1.[N+](C1C(N2CCC(=O)CC2)=NC=CC=1)([O-])=O>>[CH2:1]=[C:2]1[CH2:3][CH2:4][C:32]2([O:31][CH2:30][CH2:29][O:28]2)[CH2:6][CH2:7]1The title compound was prepared following the method reported here for Compound 2a, but using lithium-bis-trimethylsilylamide instead of buthyl lithium and carrying out the reaction at −20° C. As starting material 1,4-dioxaspiro[4.5]decan-8-one replaced 1-(3-nitro-2-pyridyl)-4-oxopiperidine. After the usual work-up procedure the residue was purified by means of automated flash chromatography (Horizon®TM-Biotage; Petroleum Ether EtOAc 95:5) to give the title compound as fluid colourless oil. Yield: 99.3%.
불러오는 중…
