3-[(3-Chlorophenyl)ethynyl]-1-oxa-2-azaspiro[4.5]dec-2-en-8-one → 3-(2-Phenylethynyl)-1-oxa-2-azaspiro[4.5]dec-2-en-8-one

HRID 2040872노트

반응식

HRID 2040872 반응식
Cl[C:2]1[CH:3]=[C:4]([C:8]#[C:9][C:10]2[CH2:14][C:13]3([CH2:19][CH2:18][C:17](=[O:20])[CH2:16][CH2:15]3)[O:12][N:11]=2)[CH:5]=[CH:6][CH:7]=1.C1(C#CC2CC3(CCC4(OCCO4)CC3)ON=2)C=CC=CC=1>>[C:4]1([C:8]#[C:9][C:10]2[CH2:14][C:13]3([CH2:19][CH2:18][C:17](=[O:20])[CH2:16][CH2:15]3)[O:12][N:11]=2)[CH:5]=[CH:6][CH:7]=[CH:2][CH:3]=1

참가 물질

3

반응물 2

HCID 566464673-[(3-Chlorophenyl)ethynyl]-1-oxa-2-azaspiro[4.5]dec-2-en-8-oneHCID 56646683HCID 56646683, 화합물

생성물 1

HCID 566466843-(2-Phenylethynyl)-1-oxa-2-azaspiro[4.5]dec-2-en-8-one

실험 절차

The title compound was synthesized using the same method described for the compound of Example 32, but starting from the compound of Example 44 instead of the compound of Example 31. The crude was purified by automated flash chromatography (SP1®TM-Biotage; Petroleum Ether-EtOAc 8:2) to give the title product as white solid. Yield: 80%.

후처리

  1. customThe title compound was synthesized
  2. customThe crude was purified by automated flash chromatography (SP1®TM-Biotage; Petroleum Ether-EtOAc 8:2)

출처 및 근거

ORD 기록
ord-3bf756c993954164bdc2a7b6f407dfbc
출처 데이터셋
uspto-grants-2013_11
특허 번호
US08580962B2

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