6-Methyl-2-(4-methylene-1-piperidyl)-3-nitropyridine → 3-[(6-Methylpyridin-2-yl)ethynyl]-8-pyridin-2-yl-1-oxa-2-azaspiro[4.5]dec-2-ene-8-carbonitrile
반응식
[CH3:1][C:2]1[N:7]=[C:6](N2CCC(=C)CC2)[C:5]([N+]([O-])=O)=[CH:4][CH:3]=1.[N:18]1[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=1[C:24]1([C:40]#[N:41])[CH2:39][CH2:38][C:27]2([CH2:31][C:30]([C:32]#[C:33][Si](C)(C)C)=[N:29][O:28]2)[CH2:26][CH2:25]1>>[CH3:1][C:2]1[N:7]=[C:6]([C:33]#[C:32][C:30]2[CH2:31][C:27]3([CH2:38][CH2:39][C:24]([C:19]4[CH:20]=[CH:21][CH:22]=[CH:23][N:18]=4)([C:40]#[N:41])[CH2:25][CH2:26]3)[O:28][N:29]=2)[CH:5]=[CH:4][CH:3]=1참가 물질
3
실험 절차
The title compound was prepared following the method described for the compound of Example 3, replacing Compound 3c with Compound 48b. The crude was purified by automated flash chromatography (SP1®TM-Biotage; gradient Petroleum ether-EtOAc from 65:35 to 4:6) to give the title compound as yellow oil. Yield: 43.4%.
후처리
- customThe title compound was prepared