8-Methylenespiro[4.5]decane → 3-[(3-Methylphenyl)ethynyl]-1-oxa-2-azadispiro[4.2.4.2]tetradec-2-ene

HRID 2040890노트

반응식

HRID 2040890 반응식
[OH:1][N:2]=[C:3](Cl)[C:4]#[C:5][C:6]1[CH:7]=[C:8]([CH3:12])[CH:9]=[CH:10][CH:11]=1.[CH2:14]=[C:15]1[CH2:24][CH2:23][C:18]2([CH2:22][CH2:21][CH2:20][CH2:19]2)[CH2:17][CH2:16]1>>[CH3:12][C:8]1[CH:7]=[C:6]([C:5]#[C:4][C:3]2[CH2:14][C:15]3([CH2:16][CH2:17][C:18]4([CH2:19][CH2:20][CH2:21][CH2:22]4)[CH2:23][CH2:24]3)[O:1][N:2]=2)[CH:11]=[CH:10][CH:9]=1

참가 물질

3

반응물 2

HCID 574938568-Methylenespiro[4.5]decaneHCID 86662877N-hydroxy-3-(m-tolyl)prop-2-ynimidoyl chloride

생성물 1

HCID 566444373-[(3-Methylphenyl)ethynyl]-1-oxa-2-azadispiro[4.2.4.2]tetradec-2-ene

실험 절차

The title compound was prepared following the procedure described for Compound 3c, using Compound 91d instead of Compound 3b and Compound 89a instead of Compound 3a. After the usual work-up procedure, the residue was purified by means of automated flash chromatography (ISOLERA®TM-Biotage; gradient Petroleum Ether-EtOAc from 97:3 to 9:1) to give the title compound as a white-yellowish solid. Yield: 55.8%.

후처리

  1. customThe title compound was prepared
  2. customAfter the usual work-up procedure, the residue was purified by means of automated flash chromatography (ISOLERA®TM-Biotage; gradient Petroleum Ether-EtOAc from 97:3 to 9:1)

출처 및 근거

ORD 기록
ord-6163f8e566004cc097db5b08b8600e4e
출처 데이터셋
uspto-grants-2013_11
특허 번호
US08580962B2

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