3-[(3-Chlorophenyl)ethynyl]-1-oxa-2,7-diazaspiro[4.4]non-2-ene-7-carboxamide → 2-[2-(3-Chlorophenyl)ethynyl]-4-oxa-3,8-diazaspiro[4.5]dec-2-ene-8-carboxamide

HRID 2040906노트

반응식

HRID 2040906 반응식
[Cl:1][C:2]1[CH:3]=[C:4]([C:8]#[C:9][C:10]2[CH2:14][C:13]3([CH2:18][CH2:17][N:16]([C:19]([NH2:21])=[O:20])[CH2:15]3)[O:12][N:11]=2)[CH:5]=[CH:6][CH:7]=1.Cl[C:23]1C=C(C#CC2CC3(CCNC3)ON=2)C=CC=1>>[Cl:1][C:2]1[CH:3]=[C:4]([C:8]#[C:9][C:10]2[CH2:14][C:13]3([CH2:18][CH2:17][N:16]([C:19]([NH2:21])=[O:20])[CH2:15][CH2:23]3)[O:12][N:11]=2)[CH:5]=[CH:6][CH:7]=1

참가 물질

3

반응물 2

HCID 566446463-[(3-Chlorophenyl)ethynyl]-1-oxa-2,7-diazaspiro[4.4]non-2-ene-7-carboxamideHCID 574938223-[(3-Chlorophenyl)ethynyl]-1-oxa-2,7-diazaspiro[4.4]non-2-ene

생성물 1

HCID 574937922-[2-(3-Chlorophenyl)ethynyl]-4-oxa-3,8-diazaspiro[4.5]dec-2-ene-8-carboxamide

실험 절차

The title compound was synthesized following the method herein described for the compound of Example 96 but replacing Compound 22c for Compound 27d. After the usual work-up procedure the crude was purified by means of automated flash chromatography (Isolera®TM-Biotage; gradient Petroleum Ether-EtOAc from 1:0 to 93:7) giving the title compound as a white solid. Yield: 76.9%.

후처리

  1. customThe title compound was synthesized
  2. customAfter the usual work-up procedure the crude was purified by means of automated flash chromatography (Isolera®TM-Biotage; gradient Petroleum Ether-EtOAc from 1:0 to 93:7)

출처 및 근거

ORD 기록
ord-9b774495ed99430683c1205116cb8980
출처 데이터셋
uspto-grants-2013_11
특허 번호
US08580962B2

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