3-Fluorophenol → HCID 57655913, 화합물

HRID 2041141노트

반응식

HRID 2041141 반응식
C(OC(=O)[NH:7][CH2:8][C:9]1[CH:14]=[CH:13][C:12](Br)=[CH:11][C:10]=1[F:16])(C)(C)C.[F:18][C:19]1[CH:20]=[C:21]([OH:25])[CH:22]=[CH:23][CH:24]=1>>[F:16][C:10]1[CH:11]=[C:12]([O:25][C:21]2[CH:22]=[CH:23][CH:24]=[C:19]([F:18])[CH:20]=2)[CH:13]=[CH:14][C:9]=1[CH2:8][NH2:7]

참가 물질

3

반응물 2

HCID 97433-FluorophenolHCID 53432589tert-Butyl [(4-bromo-2-fluorophenyl)methyl]carbamate

생성물 1

HCID 57655913HCID 57655913, 화합물수율 47%

실험 절차

Use a method similar to Preparation 30, using (4-bromo-2-fluorobenzyl)-carbamic acid tert-butyl ester (2.12 g, 7.0 mmol) and m-fluorophenol (1.57 g, 14 mmol) to give the title compound (468 mg, 47% overall).

후처리

  1. customsimilar to Preparation 30

출처 및 근거

ORD 기록
ord-1f70f4d4d06d442990ea23faf14626b9
출처 데이터셋
uspto-grants-2013_11
특허 번호
US08580780B2

반응 노트

불러오는 중…