Methanol → (2-Fluoro-4-phenoxyphenyl)-methanol

HRID 2041340노트

반응식

HRID 2041340 반응식
[F:1][C:2]1[CH:15]=[C:14]([O:16][C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)[CH:13]=[CH:12][C:3]=1[CH2:4][O:5]C1CCCCO1.CO.O.C1(C)C=CC(S(O)(=O)=O)=CC=1>CCOC(C)=O>[F:1][C:2]1[CH:15]=[C:14]([O:16][C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)[CH:13]=[CH:12][C:3]=1[CH2:4][OH:5]

참가 물질

5

반응물 3

HCID 887MethanolHCID 521998p-Toluenesulfonic acid monohydrateHCID 576563912-(2-Fluoro-4-phenoxy-benzyloxy)-tetrahydro-pyran

생성물 1

HCID 57656488(2-Fluoro-4-phenoxyphenyl)-methanol수율 95%

시약·촉매·용매 1

HCID 8857Ethyl Acetate용매

실험 절차

Mix under nitrogen atmosphere 2-(2-fluoro-4-phenoxy-benzyloxy)-tetrahydro-pyran (2.05 g, 6.8 mmol), methanol (60 mL) and p-toluenesulfonic acid monohydrate (260 mg, 1.35 mmol). Stir at ambient temperature for 16h. Dilute with EtOAc. Wash with saturated aqueous NaHCO3. Separate the organic layer, dry over Na2SO4 and concentrate in vacuo to give the desired intermediate (1.41 g, 95%). MS (ES+) m/z: 201 (M−OH)+.

후처리

  1. washWash with saturated aqueous NaHCO3
  2. customSeparate the organic layer
  3. dry with materialdry over Na2SO4
  4. concentrationconcentrate in vacuo

출처 및 근거

ORD 기록
ord-079a7785ffe544e087f4fd046ee169fa
출처 데이터셋
uspto-grants-2013_11
특허 번호
US08580780B2

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