Sodium ethoxide → 6-Ethoxypyridine-3-carbonitrile
반응식
[O-:1][CH2:2][CH3:3].[Na+].Cl[C:6]1[CH:13]=[CH:12][C:9]([C:10]#[N:11])=[CH:8][N:7]=1>C(O)C>[CH2:2]([O:1][C:6]1[CH:13]=[CH:12][C:9]([C:10]#[N:11])=[CH:8][N:7]=1)[CH3:3]참가 물질
4
실험 절차
Add sodium ethoxide (1.6 mL of 21% w/v in ethanol, 4.8 mmol) to a solution of 6-chloronicotinonitrile (612 mg, 4.41 mmol) in anhydrous ethanol (15 mL) and heat the reaction at reflux for 3 h. Cool to room temperature and stir overnight under nitrogen atmosphere. Concentrate in vacuo and dissolve the residue into dichloromethane. Wash with saturated aqueous NaHCO3, dry over MgSO4 and concentrate in vacuo to give the desired intermediate as an off-white solid (545 mg, 83%).
후처리
- temperatureheat
- customthe reaction
- temperatureat reflux for 3 h
- concentrationConcentrate in vacuo
- dissolutiondissolve the residue into dichloromethane
- washWash with saturated aqueous NaHCO3
- dry with materialdry over MgSO4
- concentrationconcentrate in vacuo
출처 및 근거
- ORD 기록
- ord-11398d6e6610440b80196300cddb7523
- 출처 데이터셋
- uspto-grants-2013_11
- 특허 번호
- US08580780B2
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