6-(4-Ethylpiperazin-1-yl)pyridin-3-amine → N-(6-(4-Ethylpiperazin-1-yl)pyridin-3-yl)-7-(2-(trifluoromethyl)phenyl)thieno[3,2-d]pyrimidin-2-amine

HRID 2042233노트

반응식

HRID 2042233 반응식
Cl[C:2]1[N:3]=[CH:4][C:5]2[S:10][CH:9]=[C:8]([C:11]3[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=3[C:17]([F:20])([F:19])[F:18])[C:6]=2[N:7]=1.[CH2:21]([N:23]1[CH2:28][CH2:27][N:26]([C:29]2[N:34]=[CH:33][C:32]([NH2:35])=[CH:31][CH:30]=2)[CH2:25][CH2:24]1)[CH3:22]>>[CH2:21]([N:23]1[CH2:24][CH2:25][N:26]([C:29]2[N:34]=[CH:33][C:32]([NH:35][C:2]3[N:3]=[CH:4][C:5]4[S:10][CH:9]=[C:8]([C:11]5[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=5[C:17]([F:20])([F:19])[F:18])[C:6]=4[N:7]=3)=[CH:31][CH:30]=2)[CH2:27][CH2:28]1)[CH3:22]

참가 물질

3

반응물 2

HCID 91616746-(4-Ethylpiperazin-1-yl)pyridin-3-amineHCID 866732222-Chloro-7-(2-(trifluoromethyl)phenyl)thieno[3,2-d]pyrimidine

생성물 1

HCID 52932073N-(6-(4-Ethylpiperazin-1-yl)pyridin-3-yl)-7-(2-(trifluoromethyl)phenyl)thieno[3,2-d]pyrimidin-2-amine수율 61.3%

실험 절차

N-(6-(4-Ethylpiperazin-1-yl)pyridin-3-yl)-7-(2-(trifluoromethyl)phenyl)thieno[3,2-d]pyrimidin-2-amine (19 mg, 61% yield) was prepared in the same manner as Step 10 of Example 1 using 2-chloro-7-(2-(trifluoromethyl)phenyl)thieno[3,2-d]pyrimidine (20 mg, 0.64 mmol) and 6-(4-ethylpiperazin-1-yl)pyridin-3-amine (13 mg, 0.064 mmol).

출처 및 근거

ORD 기록
ord-15a65c23e49e4ae9bc740dac949e9bb5
출처 데이터셋
uspto-grants-2013_11
특허 번호
US08586580B2

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