Tetrahydropyran-4-ylacetic acid → HCID 178520332, 화합물
반응식
Cl.Cl.Cl.[S:4]1[C:12]2[CH:11]=[CH:10][N:9]=[C:8]([N:13]3[CH2:18][CH2:17][N:16]([CH2:19][CH2:20][C@H:21]4[CH2:26][CH2:25][C@H:24]([NH2:27])[CH2:23][CH2:22]4)[CH2:15][CH2:14]3)[C:7]=2[CH:6]=[CH:5]1.[O:28]1[CH2:33][CH2:32][CH:31]([CH2:34][C:35](O)=[O:36])[CH2:30][CH2:29]1>>[O:28]1[CH2:33][CH2:32][CH:31]([CH2:34][C:35]([NH:27][C@H:24]2[CH2:25][CH2:26][C@H:21]([CH2:20][CH2:19][N:16]3[CH2:17][CH2:18][N:13]([C:8]4[C:7]5[CH:6]=[CH:5][S:4][C:12]=5[CH:11]=[CH:10][N:9]=4)[CH2:14][CH2:15]3)[CH2:22][CH2:23]2)=[O:36])[CH2:30][CH2:29]1참가 물질
3
실험 절차
The title compound was prepared in analogy to example 4 starting from trans-4-[2-(4-thieno[3,2-c]pyridin-4-yl-piperazin-1-yl)-ethyl]-cyclohexylamine trihydrochloride (intermediate B) (150 mg, 0.33 mmol) and tetrahydropyran-4-yl-acetic acid (50 mg, 0.35 mmol). Purification by flash chromatography on silica gel (CH2Cl2/MeOH 95:5). Off-white crystals (108 mg, 69%), MS (ISP) m/z=471.2 [(M+H)+].
후처리
- customPurification by flash chromatography on silica gel (CH2Cl2/MeOH 95:5)
출처 및 근거
- ORD 기록
- ord-b0619b115bce4e29bfefd25ccad25295