Boron tribromide → HCID 56946411, 화합물

HRID 2042550노트

반응식

HRID 2042550 반응식
C[O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[C:14]([CH3:15])=[N:13][N:12]([CH3:16])[C:11](=[O:17])[CH:10]=2)=[CH:5][CH:4]=1.B(Br)(Br)Br>C(Cl)Cl>[OH:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[C:14]([CH3:15])=[N:13][N:12]([CH3:16])[C:11](=[O:17])[CH:10]=2)=[CH:5][CH:4]=1

참가 물질

4

반응물 2

HCID 25134Boron tribromideHCID 56946410HCID 56946410, 화합물

생성물 1

HCID 56946411HCID 56946411, 화합물수율 22%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

A solution of the product from step 1 (3.2 g, 14 mmol) in CH2Cl2 (40 mL) was cooled to 0° C. and BBr3 (6.6 mL, 5.0 eq.) was added dropwise. The ice-bath was removed and the reaction was stirred at rt for 1 h, after which the reaction mixture was poured into 50 mL of ice cold saturated NH4Cl solution with stirring. The resulting solid was filtered, and washed with water (3×15 mL) then Et2O (2×15 mL) to give the product of step 2 (0.66 g, 22%): MS m/z 217 (M+H).

후처리

  1. customThe ice-bath was removed
  2. additionafter which the reaction mixture was poured into 50 mL of ice cold saturated NH4Cl solution
  3. stirringwith stirring
  4. filtrationThe resulting solid was filtered
  5. washwashed with water (3×15 mL)

출처 및 근거

ORD 기록
ord-e5615837800942998c2e5a03820cccca
출처 데이터셋
uspto-grants-2013_11
특허 번호
US08586588B2

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