1H-Azepine → 5-[4-(3-Azepan-1-yl-propoxy)-phenyl]-2-methyl-2H-pyridazin-3-one

HRID 2042559노트

반응식

HRID 2042559 반응식
Cl[CH2:2][CH2:3][CH2:4][O:5][C:6]1[CH:11]=[CH:10][C:9]([C:12]2[CH:17]=[N:16][N:15]([CH3:18])[C:14](=[O:19])[CH:13]=2)=[CH:8][CH:7]=1.[NH:20]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=[CH:21]1>>[N:20]1([CH2:2][CH2:3][CH2:4][O:5][C:6]2[CH:11]=[CH:10][C:9]([C:12]3[CH:17]=[N:16][N:15]([CH3:18])[C:14](=[O:19])[CH:13]=3)=[CH:8][CH:7]=2)[CH2:26][CH2:25][CH2:24][CH2:23][CH2:22][CH2:21]1

참가 물질

3

반응물 2

HCID 64514761H-AzepineHCID 569463035-[4-(3-chloropropoxy)-phenyl]-2-methyl-2H-pyridazin-3-one

생성물 1

HCID 249959965-[4-(3-Azepan-1-yl-propoxy)-phenyl]-2-methyl-2H-pyridazin-3-one

실험 절차

This compound was prepared as the hydrochloride salt using 5-[4-(3-chloropropoxy)-phenyl]-2-methyl-2H-pyridazin-3-one and azepine using the procedure described in Example 91 Step 5; Mp 247-8° C.; MS m/z 342 (M+H).

출처 및 근거

ORD 기록
ord-428058c0a6a9450984ebff7a82f97faa
출처 데이터셋
uspto-grants-2013_11
특허 번호
US08586588B2

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