Water → HCID 86660229, 화합물
반응식
[Br:1][C:2]1[C:7]([NH2:8])=[CH:6][N:5]=[CH:4][N:3]=1.CC(C)([O-])C.[Na+].I[CH2:16][CH2:17][CH2:18][CH3:19].O>CC(N(C)C)=O>[Br:1][C:2]1[C:7]([NH:8][CH2:16][CH2:17][CH2:18][CH3:19])=[CH:6][N:5]=[CH:4][N:3]=1참가 물질
6
반응 조건
- 온도
- 60 °C
실험 절차
A mixture of 4-bromopyrimidin-5-amine (1 g, 5.75 mmol), sodium tert-butoxide (1.11 g, 11.5 mmol) and 1-iodobutane (1.11 g, 6.03 mmol) in DMA (15 mL) was heated at 60° C. for 15 hours. The mixture was poured into water and extracted with ethyl acetate. The acetate layer was washed with water, brine, dried with MgSO4, filtered, and concentrated under reduced pressure. The residue was purified by chromatography (hexanes-EtOAc 3:1) to afford 300 mg of the title compound. MS (ESI) m/z 230 (M+H)+.
후처리
- extractionextracted with ethyl acetate
- washThe acetate layer was washed with water, brine
- dry with materialdried with MgSO4
- filtrationfiltered
- concentrationconcentrated under reduced pressure
- customThe residue was purified by chromatography (hexanes-EtOAc 3:1)
출처 및 근거
- ORD 기록
- ord-509645f6c45b4840ad0ef5bbfb32b402
- 출처 데이터셋
- uspto-grants-2013_11
- 특허 번호
- US08586596B2
반응 노트
불러오는 중…