Pivaloyl chloride → N-(3-Nitro-2,4-dichloro-benzyl)-2,2-dimethyl-propionamide

HRID 2042786노트

반응식

HRID 2042786 반응식
[CH3:1][C:2]([CH3:7])([CH3:6])[C:3](Cl)=[O:4].[N+:8]([C:11]1[C:12]([Cl:20])=[C:13]([CH:16]=[CH:17][C:18]=1[Cl:19])[CH2:14][NH2:15])([O-:10])=[O:9]>C1COCC1>[N+:8]([C:11]1[C:12]([Cl:20])=[C:13]([CH:16]=[CH:17][C:18]=1[Cl:19])[CH2:14][NH:15][C:3](=[O:4])[C:2]([CH3:7])([CH3:6])[CH3:1])([O-:10])=[O:9]

참가 물질

4

반응물 2

HCID 62493Pivaloyl chlorideHCID 56839971(2,4-Dichloro-3-nitrophenyl)methanamine

생성물 1

HCID 67958116N-(3-Nitro-2,4-dichloro-benzyl)-2,2-dimethyl-propionamide

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

2,2-Dimethyl-propionic acid chloride (0.124 mL, 1.01 mmol) is added to a mixture of 3-nitro-2,4-dichloro-benzylamine (0.28 g, 1.01 mmol) and TEA (0.35 mL, 2.52 mmol) in THF (10 mL) and it is stirred overnight. The reaction mixture is concentrated, diluted with EtOAc, washed successively with 5% aq. NaHCO3 solution and brine, dried with Na2SO4 filtered and concentrated.

후처리

  1. concentrationThe reaction mixture is concentrated
  2. additiondiluted with EtOAc
  3. washwashed successively with 5% aq. NaHCO3 solution and brine
  4. dry with materialdried with Na2SO4
  5. filtrationfiltered
  6. concentrationconcentrated

출처 및 근거

ORD 기록
ord-a6e5ba0dd04c4ab4af39ebc12a93261a
출처 데이터셋
uspto-grants-2013_11
특허 번호
US08586604B2

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